Skip to content
Peptideworth

Procedure

Methodology

Two labels sit on every compound here: how far the human evidence goes, and whether you can lawfully get it. This page is the procedure behind both — how a source is resolved, what moves a compound between tiers, and the whole register graded in one table so you can check the rubric rather than take it on trust.

Last updated · Questions: research@peptideworth.com

Where this page sits

This is the procedure: the steps, the gate, and the rubric applied to every compound on the site today. The commitments behind it — what counts as a source, how an absence claim is worded, what a calculator may output, who writes this and what we do not claim — are on the editorial policy. Neither page repeats the other.

What this rubric has graded so far

Three counts, read out of the published compound pages rather than typed here — which is the first thing this page is demonstrating.

13

Compounds graded

Each with its own evidence page, sources, and required disclosure.

79

Sources cited

Resolved live against the database that owns them, never written from memory.

2

Sold with no human data

Compounds a reader can find offered for sale that have never been tested in people.

What the grading found

The counts above describe the register. These describe the result — every one computed from the same graded products at build time, and quoted verbatim by this site’s llms.txt, which cites this page as their source.

274/379

Claims the trials don't support (72%)

Across 72 of the 94 sellers reviewed here.

152

No human trial for the use sold

The molecule has never been tested in people for what the seller sells it for.

133

Overreach despite real trials

Phase 1-3 human trials exist behind the molecule, and the claim still goes further.

Those verdicts rest on 291 trial records covering 47 distinct ClinicalTrials.gov registrations, each read from the registry rather than from memory. Seller claims were read from sellers’ own pages between 2026-08-07 and 2026-09-13, and every graded product records the claim verbatim with the URL it came from.

How a source gets onto a page

Every reference on this site is resolved through the database that owns it, in this order. A citation that cannot complete these steps does not ship — it is not softened into “research suggests” and it is not carried over from another article.

  1. Complete

    Search the record, do not recall it

    The starting point is a query against the registry or index, never a paper someone remembers. An identifier written from memory is the single most common way a fabricated citation enters a page.

  2. Complete

    Pull the record's own summary

    Authors, year, journal, title and identifier come back from the database itself and are stored exactly as returned. A DOI is read out of that record; it is never assembled from a pattern.

  3. Complete

    Open the abstract, not the summary

    The number the page is about to print has to appear in the source. “About 15%” attached to a paper reporting 14.9% is a rewrite, not a citation.

  4. Complete

    Check the claim, not the topic

    A source that is merely adjacent to a sentence does not support it. The question is whether the claim follows from the record, and a source that only shares a subject is a wrong-source failure.

  5. 5Current step

    Re-resolve before every build

    The stored reference is checked back against the live record automatically, so a citation that has drifted from its source fails the build rather than sitting on the page.

The gate that runs on every build

Editorial discipline is not a control. The check that actually keeps a fabricated reference off this site is automated and blocking, and it runs in two layers because the first layer alone is not enough.

Layer 1 — structural

Always blocking

Every inline citation marker points at a reference that exists, every reference is actually cited somewhere, no reference is duplicated, and an identifier in a link matches the identifier stored beside it. Offline, instant, and fatal.

Layer 2 — provenance

Blocking on mismatch

Every reference carrying a database identifier is resolved live and its stored title compared to the real one. A confirmed mismatch fails the build.

Why the second layer exists

A well-formatted, entirely plausible, entirely invented title sitting on a real identifier is structurally indistinguishable from a correct one. Layer 1 cannot see it — nothing about the shape of the reference is wrong. The only thing that catches it is asking the database what that identifier actually is, which is why that check is not optional and not a periodic audit.

The rubric, applied to every compound

Two labels, kept apart on purpose — what the evidence supports, and what you can lawfully obtain. The editorial policy states what each label means. What follows is the whole register with both labels attached, so the rubric can be audited rather than believed.

Ordered by how far the published human evidence goes, strongest first — then alphabetically. Nothing else moves a row. The sort reads the evidence tier and the compound's name, and nothing else: a molecule is not a company, so there is nobody for us to have a paid relationship with here. No partner flag, priority number or featured slot exists on a compound for the sort to read, and none will be added.

The seller boards are ordered differently, and we would rather you heard it here than worked it out: companies that pay us a commission are grouped above companies that do not, with the measured order running inside each group. That is stated on every board. It moves where a company sits; it never changes a number printed beside it, and it has no reach at all into the compound table above.

CompoundHuman evidenceCan you get it?Sources
Bremelanotide (PT-141)Randomized trialsFDA-approved7
SemaglutideRandomized trialsFDA-approved7
SermorelinRandomized trialsCompounding restricted5
SurvodutideRandomized trialsResearch use only6
TesamorelinRandomized trialsFDA-approved9
TirzepatideRandomized trialsFDA-approved9
CagrilintideEarly humanResearch use only6
GHK-CuEarly humanCompounding restricted5
GlutathioneEarly humanCompounding restricted5
NAD+Early humanCompounding restricted4
RetatrutideEarly humanResearch use only8
BPC-157Animal onlyCompounding restricted3
TB-500Animal onlyResearch use only5
  • Randomized trials

    6of 13

    • Bremelanotide (PT-141)
    • Semaglutide
    • Sermorelin
    • Survodutide
    • Tesamorelin
    • Tirzepatide

    Randomized controlled trials in humans, at scale.

  • Early human

    5of 13

    • Cagrilintide
    • GHK-Cu
    • Glutathione
    • NAD+
    • Retatrutide

    Small, open-label, or phase 1/2 trials. Promising, unproven.

  • Animal only

    2of 13

    • BPC-157
    • TB-500

    Rodent or cell studies. Nothing published in humans.

  • Anecdotal

    0of 13

    None on this site

    User reports and forum consensus. No controlled data.

All 13 graded compounds on the four-step ladder

One mark per compound, read off the published compound pages at build time — nothing on this figure is typed. A rung states how far the published human record goes for that molecule, never what it does in a person. Rungs run strongest at the top; randomized trials 6, early human 5, animal only 2, anecdotal 0.

By availability

  • FDA-approved4
  • Compounding restricted5
  • Research use only4

The two labels are independent, and the pairs that fall out of that are the reason they are not collapsed into one score:

  • Real evidence, still out of reach Sermorelin, Survodutide, Cagrilintide, GHK-Cu, Glutathione, NAD+ and Retatrutide. Trials have run in people; a US reader cannot lawfully obtain them today. A single score would read these as mediocre.
  • On sale, never tested in peopleBPC-157 and TB-500. Widely marketed, and the published work is animal or cell data. A single score would read these as merely unproven rather than untested.

What moves a compound between tiers

A grade is a statement about the published record, so only the published record moves it. The four steps and what each one requires:

Randomized trials

Evidence strength: Randomized trials. Randomized controlled trials in humans, at scale.

Anecdotal

0 on this site

User reports and forum consensus. No controlled data.

To reach it: Nothing published. The compound is discussed, sold and reported on by users, and no controlled study of any kind exists. This is the floor, and a compound stays here however loud the marketing is.

Animal only

2 on this site

Rodent or cell studies. Nothing published in humans.

To reach it: At least one published study in animals or cells, with the species and the model named on the page. An animal result never implies a human one, and the tier exists to stop it being read as though it did.

Early human

5 on this site

Small, open-label, or phase 1/2 trials. Promising, unproven.

To reach it: At least one published study in people — small, open-label, or an early phase. Enough to say something has been measured in humans, never enough to say it works.

Randomized trials

6 on this site

Randomized controlled trials in humans, at scale.

To reach it: Randomized, controlled, published trials in people, at a size that can support a conclusion. A registered trial does not count; a completed trial with no posted results does not count either.

Demotion is a real outcome

A grade goes down as well as up. A retraction, a failed replication, or a registered trial that completes and never posts a result all move a compound the other way — and a completed trial with nothing published is itself a finding we print rather than a gap we skip past.

The second rubric: what a seller claims, against what was tested

A compound tier grades a molecule. It says nothing about the sentence a company writes underneath the buy button, and that sentence is what a reader actually meets first. So every product on every provider review carries a second, independent grade: the company’s own words, quoted verbatim, set against the registry records for the molecule as that company sells it.

The whole register, crossed. Nothing below is typed — it is read out of the published reviews at build time, exactly like the compound table above.

  • Claim matches the trials105
  • Claim reaches past them126
  • Claim no trial supports it148
  • Phase 3 trials
    180

    86 matches the trials · 81 reaches past them · 13 no trial supports it

  • Phase 2 only
    30

    5 matches the trials · 17 reaches past them · 8 no trial supports it

  • Phase 1 only
    17

    3 matches the trials · 2 reaches past them · 12 no trial supports it

  • Observational only
    0

    No product on this site sits at this level.

  • No trial for this use
    152

    11 matches the trials · 26 reaches past them · 115 no trial supports it

379 graded products, 94 companies — evidence against claim

Each track is one evidence level and is split by how the products at that level were graded, so a segment is a share of its own row; the figure at the end of the track is that row’s count. Read off the review registry at build time. 152 of 379 products are sold on a molecule with no human trial for the use it is sold for, and 133 products that do have phase 1-3 trials behind them still carry a claim those trials do not reach. Products checked August 2026 to September 2026.

The useful cell is the top one. A claim reaching past its evidence is easy to explain away where there is no evidence at all — but 133 of these products sit on molecules with published phase 1-3 trials behind them and still carry a claim those trials do not reach. The trials existing is not the same as the claim being about them.

What a verdict is not

“Reaches past the trials” is a finding about the scope of a claim, not an accusation of bad faith and not a statement that a product is unsafe. It is also not a clinical judgment of any kind: this rubric compares a sentence to a trial record, and neither the sentence nor the record is evidence of what a compound does in you.

How an absence is bounded

The most useful sentence on this subject is usually about something that does not exist, and it is also the easiest one to overstate. Every absence claim here is written to a fixed shape — what was searched, where, and when — and the editorial policy sets out why.

The procedural half of that, which is what this page owes you:

  • The search is run against the database that would hold the thing, not against a general web search. “Nothing on PubMed” and “nothing on the internet” are different claims and only one of them is checkable.
  • The date is the date the search ran, and it is printed. An absence claim decays; a dated one decays visibly.
  • An absence of reported harm is recorded as an absence of looking whenever that is what it is. Nobody having studied an interaction is not evidence that the interaction is safe.
  • A negative result is published as a result. A search that finds nothing is a finding, and dropping the topic instead would leave the reader to assume the opposite.

What we will not publish

A site about compounds most people cannot lawfully buy is defined as much by what it refuses to print as by what it grades.

What this site will do
  • Report what a trial administered, under supervision, as a description of what was done
  • Convert a number you supply into concentration and syringe units, with the arithmetic shown
  • State plainly when a compound has no human data at all, including when it is widely sold
  • Name what is not known, and say who has not looked
What it will not
  • State, imply, default to or suggest a dose for anyone
  • Publish a protocol, a schedule, or a cycle for any compound or combination
  • List sellers for a compound under active FDA compounding restriction
  • Present an animal result as though it described a person

On seller lists for restricted compounds

Several of the most searched compounds here are under active FDA restriction, which means a compliant pharmacy declines to make them. A ranked list of who will sell you one anyway is therefore not a buying guide — it is a list of who is ignoring the restriction, and publishing it would be a recommendation we are not willing to make. The evidence pages stay; the seller table does not exist and will not until the regulatory position changes.

What a calculator here actually does

A dosing tool is the highest-liability surface on this site, because it does not describe a number — it hands one to a reader. The rule, stated in full on the editorial policy, is that our tools convert and never recommend. Mechanically, that means:

You supply the dose
Every field ships empty. There are no presets, no “typical” placeholder, and no default that a reader could mistake for a suggestion.
We supply the arithmetic
The output is your figure converted into concentration and syringe units, with warnings when it exceeds the vial or the syringe. If a tool cannot compute without inventing a number, it computes nothing.

How often this is checked again

A date on a page is a claim about work, and a freshness stamp with no re-reading behind it is a lie with a date on it. What actually gets re-opened, and when:

Citations

Every build

Automatic. Every stored reference is re-resolved against the live record, and a confirmed mismatch stops the deploy.

Evidence grades

When a readout lands

A trial reporting, a registry status changing, a retraction, or a regulator action triggers a re-read of the compound page — not a scheduled sweep, because evidence does not arrive on a schedule.

Availability labels

Quarterly

Approval status and compounding restrictions are re-checked against the regulator's own database, because this is the label most likely to be quietly out of date.

When this procedure gets it wrong

It will. A number is read out of the wrong arm of a trial, a grade lags a readout, an availability label is a quarter stale. When that happens the fix is published as a fix — what was wrong, what it is now, and when it changed — on the corrections page, which is also where to send one. A claim on this site that you cannot trace back to its source is worth reporting, and it is the report we most want to receive.

Cite this dataset

The 379 graded products and 13 compound grades on this page are published under CC BY 4.0. Republish any figure here with attribution. If you are quoting a single compound’s grade rather than the whole register, cite that compound’s page instead — it carries the references behind the grade.

Peptideworth, "Peptideworth peptide evidence and seller-claim grading", https://peptideworth.com/methodology (379 rows, verified 2026-08-07 to 2026-09-13).